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Sheffield United are having a tremendous season back in the Premier League and manager Chris Wilder has produced miracles to ensure the Blades are staying well away from a relegation fight.
The fact they are just a point off Manchester United, who are fifth, speaks volumes for the work being done at Bramall Lane, and the club will be looking to make progress in the cup on Saturday afternoon.
They travel down to the capital to face championship Millwall, with the Lions themselves in cracking form and challenging for a playoff berth. They are unbeaten in six outings and easily dispatched Newport 3-0 in the previous round.
However, surprisingly they have failed to make the New Den a fortress this season and with only three championship maximums secured, will do well to stop United from making the next round.
Sheffield have only lost twice on their travels in the top flight and although they often draw, this still represents a drop in class and I fully expect it will be a happy team bus on the way back up the M1.
Newcastle struck twice in injury time at Everton on Tuesday to rescue an unlikely point and that confidence booster will leave them expecting to beat League One Oxford at St James Park next.
It’s well documented the Toon are not overly prolific in front of goal, but they did bag four against Rochdale in the last round.
Oxford are looking for promotion from League One but are without a win in their last four league outings, and it’s hard to envisage an upset in the North East.
Attacking weapons Miguel Almiron and Joelinton should enjoy the greater space and time against lower league opponents and can showcase their undoubted talents.
Newcastle fans would love a long cup run and a big crowd can cheer them on to victory here.
Burnley produced their best result of the season on Wednesday evening when running out 2-0 winners at Old Trafford to stun Manchester United.
Chris Wood was again on the scoresheet and is in tremendous form. Goalkeeper Nick Pope looks a certainty to be in the England Euro 2020 squad this summer and the team have a nice balance to it.
The Clarets have put a seven-point cushion between themselves and the bottom three and will look to ensure survival along with a cup run.
They host fellow PL side Norwich, who are currently sitting at the foot and will surely be concentrating on trying to preserve their top-flight status.
The Canaries were beaten 2-0 at Turf Moor back in September and a similar scoreline can be expected. It would be no surprise to see the visitors rest their main squad ahead of some difficult league fixtures and Burnley should be celebrating Saturday evening.
Chelsea are away at Hull in the live TV game, where the producers are obviously looking for a potential upset.
The Tigers are hovering around mid-table in the championship but still within striking distance of the playoffs and in forward Jarrod Bowen, they have one of the most feared marksmen in the section.
They are frustratingly inconsistent, which is hampering their promotion bid, and will need to produce their best performance of the season to lower the colours of Frank Lampard’s Chelsea.
The Pensioners have a good record over the years in the FA Cup and as well as securing a top-four position in the PL, they will be looking for success in the most famous domestic cup competition in the world.
With Callum Hudson Odoi back in the fold and Tammy Abraham proving the goal threat, they should navigate this tie with the minimum of fuss.
Liverpool have one hand on the PL title and although they fielded a weakened starting eleven in the previous round, were still able to beat local rivals Everton 1-0.
They were suffering with a lengthy injury list at the time but the youngsters who stepped in did a great job in helping them to qualify.
They now face the trip to League One Shrewsbury, with the hosts and thousands watching on live TV looking for an almighty upset.
The old Gay Meadow witnessed some memorable cup shocks back in the day, and the Shropshire side would love nothing more than to beat the current Champions League holders at their new ground.
They caused a big surprise in the last round, eliminating high-flying Championship Bristol City, but surely lightning can’t strike twice and Liverpool have too much depth in their squad to allow another major scalp.